Fluorescent species of 7-azaindole and 7-azatryptophan in water
نویسندگان
چکیده
منابع مشابه
Rotationally resolved electronic spectroscopy of water clusters of 7-azaindole.
The rotationally resolved electronic spectra of the electronic origin of the 7-azaindole-(H(2)O)(1) and of the 7-azaindole-(H(2)O)(2) clusters have been measured in a molecular beam. From the rotational constants the structures in the S(0) and S(1) electronic states were determined as cyclic with the pyrrolo NH and the pyridino N atoms being bridged by one and two water molecules, respectively....
متن کاملHydrogen Transfer in 7-Azaindole
Ab initio calculations are reported on 7-azaindole and the 1:1 complexes between 7-azaindole and water and methanol. Geometry optimizations using restricted Hartree−Fock wavefunctions and a double ζ plus polarization basis set were performed on the tautomeric minima and the transition states connecting these minima. Energetics were predicted using second-order perturbation theory. The ground st...
متن کاملPhotophysics and Biological Applications of 7-Azaindole and Its Analogs
7-Azaindole is the chromophoric moiety of 7-azatryptophan, which is an alternative to tryptophan as an optical probe of protein structure and dynamics. The great power of the 7-azaindole chromophore is that it is red shifted both in absorption and emission from tryptophan, that its fluorescence decay is single exponential in water under appropriate conditions, and that its emission is sensitive...
متن کاملDetermination of the excited-state structure of 7-azaindole-water cluster using a Franck-Condon analysis.
The change of the 7-azaindole-water cluster structure upon electronic excitation was determined by a Franck-Condon analysis of the intensities in the fluorescence emission spectra obtained via excitation of five different vibronic bands. A total of 105 emission band intensities were fitted, together with the changes of rotational constants of one isotopomer. These rotational constants have been...
متن کاملSynthesis and Photophysics of the Optical Probe N1-Methyl-7-azatryptophan
The development of a new intrinsic optical probe of protein structure and dynamics, Nl-methyl-7azatryptophan (1M7AT), is reported. The utility of this nonnatural amino acid derivative lies in its singleexponential, long-lived fluorescence decay (21.7 f 0.4 ns) and in its high fluorescence quantum yield (0.53 f 0.07). Its absorption and emission maxima are red-shifted 10 and 65 nm, respectively,...
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ژورنال
عنوان ژورنال: The Journal of Physical Chemistry
سال: 1993
ISSN: 0022-3654,1541-5740
DOI: 10.1021/j100111a011